import wx app = wx.PySimpleApp() dlg = wx.MessageDialog(None, "Is this explanation OK?",'A Message Box',wx.YES_NO | wx.ICON_QUESTION) retCode = dlg.ShowModal() if (retCode == wx.ID_YES): print "yes" else: print "no" dlg.Destroy() retCode = wx.MessageBox("Is this way easier?", "Via Function",wx.YES_NO | wx.ICON_QUESTION)